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C2nr11689h 1010..1015
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The glycogen synthase kinase-3 inhibitor LY2090314 specifically impaired CYP2B6 activity during in vitro evaluation of cytochrome P450 (P450) enzyme induction in human hepatocytes. CYP2B6 catalytic activity was significantly decreased following 3-day incubation with 0.1–10 mM LY2090314, on average by 64.3%6 5.0% at 10 mM. These levels of LY2090314 exposure were not cytotoxic to hepatocytes and ...
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ژورنال
عنوان ژورنال: Transactions of the Architectural Institute of Japan Summaries of Technical Papers
سال: 1965
ISSN: 2433-0035
DOI: 10.3130/aijsaxxe.40.0_15